Day II – 23^rd Feb.

Technical Session III

The second day of seminar began with a prayer session after which report of the previous day was read by Ms Suella Baretto.

The third technical session began under the charge of Ms Kathleen Pinto with welcoming the chairman, Prof. Lalit Kukreja and the resource persons Prof. K.S Rane, dept. of Chemistry-Goa University and Dr. Mansing Shingte, Group Sanofi-Aventis, Goa . Prof. Kukreja addressed the gathering and appreciated the previous days efforts of the seminar. Prof. K.S.Rane gave a presentation on the topic “Aerosol route to synthesize nanomaterials for biomedical, catalytic and electronic applications”. He began by saying that size and morphology play an important role in the performance of particles and particle sizes should be uniform. He further said that bulk synthesis processes lead to agglomerated products, but nanoparticles are unagglomerated thus manufacturing on a large scale is a major challenge. He said he used spray pyrolysis method which leads to uniform product particles of narrow size distributions by aerosolizing followed by pyrolysis. He used aluminium oxide and iron oxide for synthesis. He listed the applications of iron oxide in biomedical field as contrasting agent for MRI, treatment of tumor necrosis, as a carrier for targeted drug delivery, hyperthermic treatment to malignant cells and biological heating applications.

Finally he stated the conclusions of his findings.

The next presentation was given by Dr. Mansing Shingte who gave an overview of novel drug delivery systems. He explained that drug delivery involves a delivery vehicle and method of administration and enables new molecules and enhances life cycle management. He said that NDDS meets clinical needs, reduces side effects, optimizes PK profile, delivery by using improved components etc. he discussed the ideal drug delivery system which should be inert, biocompatible, mechanically strong, comfortable for patients and so on. He then spoke about the various drug delivery systems, biodegradable systems, OROS technology, osmotic – controlled release oral delivery systems, ring cap technology, pulsicap technology, transdermal drug delivery system, inhalation, nasal and continuous drug delivery systems. He concluded by saying that fruits are genetically engineered to deliver vaccines. Dr. Shingte answered then answered the queries of the participants and assured to collaborate with the educational institutes for development of student knowledge with respect to the pharma industry.

Dr. Lisette D’Souza was the chairperson for the second half of the technical session III. 

The first resource person Dr. Solimabi Wahidulla, Scientist,NIO gave a presentation on Dru discovery and Drug delivery. She said that drug discovery is a complex, interdisciplinary pursuit of chemistry, pharmacology and biosciences and has benefited mankind over last several years. She stated that marine environment is potential source of bioactive metabolites which could serve as a lead molecules for the development of drugs. She explained the processes involved in drug development of drugs. She explained the processes involved in drug development from a collection of biological matter to the clinical evaluation. She gave an insight to the four projects she has worked on. She also spoke of the advantages of controlled release system which is the most important factor when oral or inject able formulation can not be used. The nanomedicine based diagnostics developed to date include gold nanoshells, iron oxide crystals, quantum dots. She also spoke of the role of nanotechnology in cancer therapy.

The next resource person, Mr. R.S.N. Babu, Goa University spoke about Nano and microparticles as controlled Drug Delivery Devices. He said that nano drugs improve efficacy, reduce toxicity, maintain efficiency and have on-site prompt delivery. He said that nano particles can be directed through blood flow and their interaction with themselves or with the biocomponents. He elaborated the flow of nanoparticles in vivo( in body)such as flowing blood in adhesion to tissues, static conditions like tumors etc. and also stated that nanoparticles flow and movement are size and route dependent and are influenced by convention. He stressed that structural properties such as size and shape play an important role in drug delivery and suggested using Bacteria as a natural mode to deliver nano drugs.

This was followed by three paper presentations. Ms. Gayatri Rane, Goa University who presented paper on Titanium Oxide rods: Synthesis, characterization and their use as supports for a novel gold deposition method. Ms. R. Swetha Iyer, Mount Carmel College , Bangalore presented on current status and challenges of nano materials in pharma industry. Dr. Rajesh Pednekar, DM’s College, Mapusa presented a paper on Novel applications of Science and Nanotechnology.

Mr. Dhrubjyoti Kalita’s presentation on drud delivery using nanostructures explained that drug delivery comprises of polymeric nanoparticles magnetic nanoparticles, liposomes, ceramic nanoparticles and micelles. He discussed problems in drug delivery and said that nano particles for therapy and imaging are two sides of the same coin. He discussed key points in selecting polymers and explained polymeric nanoparticulate systems and multi functional nano carriers. The possible modes of ocular drug delivery he discussed wre topical, sub conjunctival and intra vitrial. He explained development of peptide linkers based on ringsdof model. The

The last presentation of the seminar was by Dr. G.M. Nasseruddin, Vice Principal and Head of Dept. of Chemistry Poona College. He spoke on Designing of drugs through computers followed by an attempt for synthesis. He explained the designing of the derivatives of alpha-aryl propanoic acid. Dr. Nasseruddin discussed properties of heat of formation, ionization potential and dipole movement of ibuprofane and eboprofane and the scheme for their synthesis. The session concluded with a panel discussion.